AOD9604 1kits (10Vials)

AOD9604 – Full Details & Benefits 1. Basic Introduction AOD9604 is a synthetic 16‑amino‑acid peptide derived from the C‑terminal fragment (aa 176–191) of human growth hormone (hGH) . A tyrosine is added at the N‑terminus for stability, and a disulfide bond between two cysteines makes it cyclic. Other names : hGH Frag 176–191 (modified) Molecular formula : C₇₈H₁₂₃N₂₃O₂₃S₂ Molecular weight : ~1,815 Da (free base) Appearance : White lyophilized powder Purity : ≥98% (HPLC) Classification : Lipolytic / metabolic peptide (research use only) Key feature : Mimics GH’s fat‑burning effects without raising IGF‑1 or disrupting glucose/insulin . 2. Mechanism of Action AOD9604 works mainly via beta‑3 adrenergic receptors (β₃‑AR) in fat cells: Upregulates β₃‑AR → adipocytes become more sensitive to fat‑breakdown signals. Activates cAMP‑PKA‑HSL cascade → triggers hormone‑sensitive lipase (HSL) → breaks down stored triglycerides into free fatty acids (FFAs) . Inhibits acetyl‑CoA carboxylase (ACC) → reduces new fat synthesis (lipogenesis) . No IGF‑1 stimulation → no anabolic/muscle growth side effects of full hGH. No insulin resistance / blood sugar spikes → safer metabolic profile. 3. Main Benefits & Effects 1. Targeted Fat Loss (Lipolysis) Burns stubborn subcutaneous & visceral fat (abdomen, hips, thighs). Preferentially targets obese adipocytes over lean ones. In clinical trials: ~ 1.8–2.6 kg fat loss over 12 weeks (1 mg/day) vs. placebo. 2. Boosts Resting Metabolism & Energy Increases basal energy expenditure → burn more calories at rest. Enhances fat oxidation → uses FFAs for fuel. 3. Preserves Lean Muscle Mass Fat loss without muscle loss (no IGF‑1 = no muscle growth, but no catabolism either). Good for body recomposition (fat down, muscle stable). 4. Metabolic Safety (vs. hGH) No IGF‑1 elevation → avoids acromegaly risk. No glucose/insulin disruption → safe for insulin‑sensitive users. No impact on natural hormone feedback . 5. Joint & Cartilage Support (Research) Preclinical data: may enhance proteoglycan synthesis → supports osteoarthritis repair. 4. Dosage & Administration (Research Use) Standard dose : 250–500 mcg subcutaneous injection (abdomen/thigh) once daily . Cycle length : 4–12 weeks ; 4–8 weeks off before repeating. Reconstitution : Mix with bacteriostatic water (1–2 mg/mL). 5. Safety & Side Effects Common Mild (Transient) Mild injection site redness/itching. Slight headache or lightheadedness (rare). No flu‑like symptoms (unlike some peptides). Key Safety Advantages No IGF‑1 surge → safe long‑term (research). No insulin resistance → suitable for metabolic management. Non‑addictive , no hormonal dependency. Warnings Not approved by FDA for human use (research only). Banned in competitive sports (WADA list). Not for pregnant/nursing women or children. 6. Summary AOD9604 is a selective lipolytic peptide that delivers GH‑like fat loss without IGF‑1 or glucose side effects . Its core benefits are targeted fat reduction, higher resting metabolism, and lean muscle preservation , making it popular in peptide research for weight management and body recomposition.