5-amino-1mq—1kits (10Vials)

5‑Amino‑1MQ – Full Details & Benefits 1. Basic Introduction 5‑Amino‑1MQ (full name: 5‑Amino‑1‑methylquinolinium ; abbreviations: 5A1MQ / NNMTi ) is a potent, selective small‑molecule inhibitor of the enzyme NNMT (nicotinamide N‑methyltransferase) . It is not a peptide —a synthetic quinolinium‑class compound designed to reset cellular metabolism by blocking the “methyl sink” pathway. CAS : 42464‑96‑0 Molecular weight : ~159.6 Da Form : Lyophilized white powder (injectable) or oral capsule Purity : ≥99% HPLC (research grade) Key target : NNMT (highly expressed in fat, liver, muscle) Status : Preclinical research compound (not FDA/EMA approved for human use 2. Core Mechanism of Action (NNMT Inhibition) NNMT is an enzyme that drains cellular energy: it uses SAM (methyl donor) to convert nicotinamide (NAM) into 1‑MNA , which depletes NAD⁺ and drives fat storage, insulin resistance, and aging. 5‑Amino‑1MQ blocks NNMT → 3 critical shifts: NAD⁺ Restoration : NAM is redirected to the NAD⁺ salvage pathway → higher NAD⁺ levels. Sirtuin Activation : NAD⁺ fuels SIRT1/SIRT3 → boosts mitochondrial function & fat oxidation. Reduced Lipogenesis : Blocks new fat cell formation & shrinks adipocyte size. Unique advantage : Works via metabolic rewiring , not appetite suppression (unlike GLP‑1s). 3. Key Benefits (Preclinical Research Proven) 1. Powerful Fat Loss & Body Recomposition Reduces visceral & white fat (without lowering food intake). Shrinks adipocytes & inhibits new fat formation (lipogenesis). Preserves lean muscle —no muscle loss during fat loss. In rodents: −5–8% body weight in 4–6 weeks via higher energy expenditure. 2. Metabolic Health & Insulin Sensitivity Lowers fasting glucose & HbA1c ; improves glucose tolerance. Reduces insulin resistance (lower HOMA‑IR) → supports type 2 diabetes research. Lowers liver fat (NAFLD/MAFLD) & hepatic inflammation. 3. NAD⁺ Boost & Longevity Support Elevates NAD⁺ (critical for energy, DNA repair, anti‑aging). Activates sirtuins (SIRT1/3) → delays cellular senescence & improves skin elasticity. Enhances mitochondrial biogenesis (PGC‑1α upregulation) → more efficient energy production. 4. Muscle & Physical Performance Reverses sarcopenia (age‑related muscle loss) in aged models. Increases endurance & VO₂ max —exercise‑mimetic effects. Speeds recovery from training/injury via reduced oxidative stress. 5. Neuroprotection & Cognitive Support Improves mitochondrial function in neurons → supports memory & focus. Anti‑inflammatory in brain tissue → potential for neurodegenerative research. 4. Safety & Research Notes Well‑tolerated in preclinical models ; no severe adverse effects at standard research doses. No hypoglycemia risk (unlike insulin/GLP‑1s). Common mild effects : transient headaches, mild GI upset (rare). Research use only : Not approved for human medical treatment. 5. Summary 5‑Amino‑1MQ is a next‑generation metabolic small molecule that targets NNMT to restore NAD⁺ , activate sirtuins, and drive fat loss while preserving muscle. It offers a unique appetite‑independent approach to body recomposition, metabolic health, and longevity—ideal for research into obesity, insulin resistance, fatty liver, and age‑related decline.